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KMID : 0861120130170020157
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Korean Journal of Oriental Preventive Medicine
2013 Volume.17 No. 2 p.157 ~ p.168
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The Toxicological Effects of Ahnjon-Yichun-Tang in Pregnant Rats and Fetuses
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Kim Bum-Hoi
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Abstract
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The objective of this study was to characterize the adverse effects of Ahnjon-Yichun-Tangduring early pregnancy. Following successful mating, female Sprague-Dawleyrats were given Ahnjon-Yichun-Tang (AYT) extract by oral administration daily with dose of 150 mg (n=10), 300 mg (n=10), 450 mg (n=10) for 20 days of pregnancy. The rats in Control group (n=10) were orally administrated with Saline. All pregnant rats of Ahnjon-Yichun-Tang-treated and Control groups were sacrificed on day 20 of pregnancy. The pregnancy outcome was determined and the internal and reproductive organs of pregnant rat were observed. The fetuses were examined for the presence of various developmental toxic end points and stained with alcianblue and alizarinred S, and observed skeletal malformations. The results obtained in this study represent that there is no significant changes between Control and Ahnjon-Yichun-Tang-traeted groups in body weight, organ weight, blood chemistry values, hematological values and pregnancy indexes of pregnantrat. The skeletal malformation of fetus was not observed as well. These results suggest that oral administration of Ahnjon-Yichun-Tang does not produce either maternal or developmental toxicity.
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KEYWORD
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Pregnant toxicity, Ahnjon-Yichun-Tang, SD rat, ALT, AST, BUN, Creatinine
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